Think autoimmunity, breath autoimmunity, and learn autoimmunity
نویسندگان
چکیده
منابع مشابه
[Autoimmunity].
Autoimmune diseases comprise a large, diverse group of diseases characterized by a humoral or cell-mediated immune response against the constituents of the body's own tissues. In cases in which the host is sensitized with a tissue-specific antigen, a single pathological immune reaction occurs in the target organ. In those cases in which the host is sensitized with either a single tissue nonspec...
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Gene association studies are less appealing in cancer compared to autoimmune diseases. Complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, such as Grave’s disease, on which a large body of multicentre data is accumulated. For years t...
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MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the 3' UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-146a has obtained an importance as a modulator of differ...
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Background: The relationship between thyroid autoimmunity and breast cancer is a challenging subject. We aimed to investigate this association in women with breast cancer. Methods: In this descriptive study, 41 women with newly diagnosed breast cancer before receiving any pharmacologic treatment and 38 healthy age-matched women were enrolled. Anti TPO Ab (anti-thyroid peroxidase antibodies), FT...
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A dangerously mutagenic protein is targeted to a single genomic site by ssDNA, report Ronai et al. (page 181). High frequency mutation at the immunoglobulin V region improves antibody affinity and specificity as part of the adaptive immune response. AID (activation-induced cytidine deaminase), which converts deoxycytidines to deoxyuridines, initiates this mutation process. These conversions the...
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ژورنال
عنوان ژورنال: Clinical Rheumatology
سال: 2019
ISSN: 0770-3198,1434-9949
DOI: 10.1007/s10067-019-04540-2